Police said they were looking for four men Monday in connection with a lethal stabbing on an Upper Manhattan street that killed a man a couple of blocks from his home.

NYPD officials said 45-year-old Omar Lopez died after being stabbed five times around 4:30 a.m. Sunday on Nagle Avenue near Arden Street in Inwood. He had been hanging out on the sidewalk before he was attacked in front of the Karamelo restaurant, officials said.

First responders took Lopez to Harlem Hospital, where he was pronounced dead. Police said he lived in an apartment building just a few minutes’ walk from where he was stabbed.

The NYPD did not release information about a potential motive for the attack, but published surveillance footage of one of the suspects.

One of the people police say they're looking for in connection with the fatal Inwood stabbing on Sept. 21, 2025

Elsewhere in Manhattan, detectives were investigating a separate stabbing and shooting that happened Sunday in NoMad near the route of the Mexican Independence Day Parade, according to police.

A 24-year-old man was stabbed in his buttocks at East 28th Street and Madison Avenue just before 5 p.m., and a 17-year-old girl was shot in her shoulder minutes later at East 27th Street and Park Avenue South, officials said. Both were taken to Bellevue Hospital in stable condition, and police said they took someone into custody in connection with the shooting.

The NYPD said the incidents, which took place after the parade officially ended, were unrelated to each other, and police were still looking for a suspect in the stabbing.

Police data through Sept. 14 shows homicides and felony assaults in the 34th Precinct, which includes Inwood, fell 80% and 9%, respectively, from their levels at the same time last year. In the 13th Precinct, which includes NoMad, felony assaults rose almost 25%.

Citywide, homicides dropped 17% and felony assaults 1% year over year, according to the data.

This is a developing story based on preliminary information from police and may be updated.